产品货号：
Z21941
中文名称：
Neurokinin-1 receptor/TACR1抗体
英文名称：
Anti-Neurokinin-1 receptor/TACR1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Neurokinin-1 receptor/TACR1 Antibody |
| 指标别名 | Neurokinin-1 receptor;NK 1 receptor;NK 1R;NK1R;NK-1R;NKIR;SPR;Substance P receptor;TAC1R;tachykinin receptor 1;TACR1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | TACR1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human TACR1 (264-291aa FHIFFLLPYINPDLYLKKFIQQVYLAIM),different from the related mouse sequence by one amino acid,and from the related rat sequence by two amino acids. |
| 实际分子量 | 48KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The tachykinin receptor 1 (TACR1),also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR),is a G protein coupled receptor found in the central nervous system and peripheral nervous system.The endogenous ligand for this receptor is Substance P,although it has some affinity for other tachykinins.The protein is the product of the TACR1 gene.Tachykinin receptor 1 consists of 407 amino acid residues,and it has a molecular weight of 58.000.Tachykinin receptor 1,as well as the other tachykinin receptors,is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops,an amino-terminus and a cytoplasmic carboxy-terminus.The loops have functional sites,including two cysteines amino acids for a disulfide bridge,Asp-Arg-Tyr,which is responsible for association with arrestin and,Lys/Arg-Lys/Arg-X-X-Lys/Arg,which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system.It is present in neurons,brainstem,vascular endothelial cells,muscle,gastrointestinal tracts,genitourinary tract,pulmonary tissue,thyroid gland and different types of immune cells.The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain,the contraction of smooth muscles and inflammation.Tachykinin receptor 1 antagonists have also been studied in migraine,emesis and psychiatric disorders.In fact,aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression.Other diseases in which the tachykinin receptor 1 system is involved include asthma,rheumatoid arthritis and gastrointestinal disorders. |
| Uniprot ID | P25103 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | tachykinin receptor 1 |
| 蛋白名全称 | Substance-P receptor |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：Neurokinin-1 receptor/TACR1抗体，Neurokinin-1 receptor抗体，TACR1多抗，Anti-Neurokinin-1 receptor/TACR1 Antibody